9 Reasons You’re Not Getting the Best Results on GLP-1 Medications

1. Not Reaching the Maintenance Dose

GLP-1 treatments typically start at a low dose to reduce side effects, with gradual increases. If you remain on a starter dose for too long or haven’t titrated appropriately, results may be limited.
Why it matters: Most clinical trials showing significant weight loss used full therapeutic, or maintenance, doses.^1,2

2. Irregular or Missed Doses

Missing doses or taking them at inconsistent intervals can blunt the medication’s effect.
Why it matters: GLP-1 medications rely on stable levels in your system to regulate appetite, digestion, and glucose control.³

3. Not Eating Enough Protein

Low protein intake can lead to muscle loss rather than fat loss.
Why it matters: Preserving lean muscle helps maintain metabolism and supports healthier, more sustainable weight loss.⁴

4. Drinking Too Many Liquid Calories

Alcohol, smoothies, juices, and speciality coffees can deliver large amounts of calories without making you feel full.
Why it matters: GLP-1 drugs reduce appetite, but they cannot offset high-calorie drinks.⁵

5. Eating High-Calorie, Low-Volume Foods

High-calorie, low-volume foods like chocolate, pastries, or takeaways can sabotage weight loss efforts.
Why it matters: GLP-1 medications help reduce appetite, but they cannot offset calorie-dense foods.⁶

6. Not Focusing on Strength Training

Without resistance training, the body may lose muscle along with fat.
Why it matters: Maintaining lean mass supports metabolism and long-term weight loss.^7,8

7. Stress and Poor Sleep

Chronic stress and sleep deprivation can increase cravings and slow fat loss.
Why it matters: Cortisol and hormonal changes can undermine appetite control.^9,10

8. Expecting Results Too Quickly

GLP-1 medications work gradually; maximum results are often seen after 9–12 months.
Why it matters: Weight loss continues progressively over many months with therapeutic doses.^1,11

9. Underlying Medical Conditions or Other Medications

Conditions such as hypothyroidism, insulin resistance, perimenopause, or PCOS can slow results. Some medications (e.g., steroids, certain antidepressants, antipsychotics) may also influence weight.
Why it matters: Metabolic rate and weight loss can be affected by underlying conditions and concomitant medications.^12,13

Summary

GLP-1 medications, such as semaglutide and tirzepatide, are highly effective tools for weight management when combined with proper dosing, consistent adherence, and healthy lifestyle habits. Achieving optimal results requires personalised clinical guidance, including dose adjustments and monitoring of nutrition and physical activity.

Consulting your PrivateDoc clinician ensures that your treatment plan is tailored to your individual needs, maximising weight loss opportunities while supporting long-term metabolic health.