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How long does a pack of Mysimba last?

When you first start Mysimba

When you first start Mysimba, a single pack of 112 tablets lasts 5 weeks.

Your medicine should be taken as advised by us. When you take Mysimba you will gradually increase your dose over a four-week period until you reach what is called the maintenance dose. This is the dose at which you will continue to take Mysimba.

You increase your dose as follows:

Mysimba dose dose-escalation period
Mysimba dose dose-escalation period
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Ongoing maintenance dose (after 4 weeks)

Once you're past the 4-week dose-escalation period and have achieved the maintenance dose, a single pack of 112 tablets lasts 4 weeks.

Mysimba maintenance dose

How do I take Mysimba?

You should swallow your tablets whole with plenty of water, with or immediately after food. They are a prolonged-release formulation, so you must never crush, chew or cut the tablets as this will affect the rate at which the active ingredients are released into your body.

The maximum recommended dosage of Mysimba is two tablets twice a day. If you do not lose at least 5% of your body weight after 16 weeks of treatment, your doctor will evaluate if you should continue taking Mysimba.

Always take this medication exactly as your doctor tells you to. You can find full details in the patient information leaflet. Additional information and guidance on Mysimba can also be found at

Mysimba is a prolonged release tablet which is blue in colour. The tablets are round and have NB-890 embossed on one side.

What are the possible side effects of taking Mysimba?

As with all medication, Mysimba can be associated with unwanted side effects. Although generally mild some of these can be more severe which may result in the treatment being discontinued.

Very common side effects (may affect more than 1 in 10 people):

  • Insomnia
  • Anxiety & agitation
  • Headache
  • Feeling restless
  • Abdominal pain & constipation
  • Nausea & vomiting
  • Joint & muscular pain

Common side effects (may affect up to 1 in 10 people):

  • Hypersensitivity reactions (e.g. rash, itch)
  • Reduction in lymphocyte cells count
  • Depression, irritability & increased energy
  • Dizziness, vertigo & tinnitus
  • Tremor
  • Headache
  • Tiredness, difficulty concentrating & lack of energy
  • Watery eyes
  • Palpitations, hot flushes & excessive sweating
  • Chest pain
  • Decreased appetite, diarrhoea
  • Taste disturbances, dry mouth & toothache
  • Delayed ejaculation
  • Fever & chills
  • Hair loss

Uncommon side effects (may affect up to 1 in 100 people):

  • Cold sores
  • Athlete’s foot
  • Swollen glands in the neck, armpit or groin
  • Excessive loss of body waterj dehydration
  • Loss of appetite
  • Increased appetite & weight gain
  • Abnormal dreams, nightmares
  • Flushing
  • Feeling nervous, feeling spacey, tension, agitation, mood swings, hallucinations, confusion, severe suspiciousness (paranoia), disorientation
  • Loss of sexual desire
  • Tremor of the head or a limb which increases when trying to perform a particular function
  • Balance disorder
  • Loss of memory, mental impairment
  • Almost fainting
  • Motion sickness
  • Ear pain, ear discomfort
  • Visual disturbances, blurred vision, eye irritation, pain or swelling, increased sensitivity to light
  • Nasal discomfort, congestion, runny nose, sneezing, sinus disorder
  • Sore throat, increase in mucus that is coughed up, difficulty in breathing, disorder of the voice, cough, yawning
  • Fluctuating or increased blood pressure
  • Pain in the lower part of the abdomen
  • Burping
  • Swelling of the lips
  • Passage of fresh blood through the anus usually in or with stool
  • Hernia
  • Passing wind (flatulence), haemorrhoids, ulcer, cavities
  • Inflammation of the gallbladder
  • A problem with the spine where supporting disc between two bones (vertebra) bulges out
  • Jaw & groin pain
  • A disorder characterised by a sudden compelling urge to urinate, abnormally frequent urination, painful urination
  • Irregular menstrual cycle, vaginal bleeding, dryness of the female vulva & vagina
  • Difficulty in getting or keeping an erection
  • Feeling abnormal or weakness
  • Thirst, feeling hot
  • Coldness of extremities (hands, feet)
  • Increased creatinine levels in the blood (indicating loss of kidney function)
  • Increased liver enzymes and bilirubin levels, liver disorders, hepatitis
  • Decreased haematocrit (indicating loss of red blood cell volume)
  • Acne, oily skin

There are further rare and very rare side effects that occasionally people can experience when taking Mysimba, for complete details about all side effects always read the Patient Information Leaflet.

Did you know?

Over 40% of the population has tried to lose weight at some point in the last 5 years – so you’re certainly not alone

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