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Dr Ruchira Karunadasa
Authored on 1 Dec 2025 by Dr Ruch Karunadasa,Medically reviewed 9 May 2026 by Adeel Arshad.Next review due: 9 May 2027

9 Reasons You’re Not Getting the Best Results on GLP-1 Medications

With the Evidence

GLP-1 receptor agonists, such as semaglutide (Wegovy or Ozempic) and tirzepatide (Mounjaro), are proven treatments for weight management and type 2 diabetes in the UK when prescribed appropriately. In routine care, titration, follow-up, and what to do after a missed dose should follow the UK product and patient information for your medicine, alongside what you agree with your prescriber, not informal dosing advice from social media. The same active ingredients may be marketed under different names in other countries (for example Zepbound for weight-loss tirzepatide in the United States). Some people still see slower or smaller changes than expected. Below are nine evidence-based reasons why results may vary, grounded in clinical guidance and the research cited at the end of the article.

1. Not Reaching the Maintenance Dose

GLP-1 injections usually start low and step up to limit nausea and other side effects. Staying below a maintenance-equivalent dose for too long, or delaying agreed increases, often caps how much change you will see on scans or the scales.
In the trials: The largest weight-loss results came from participants who reached and stayed on full maintenance doses.1,2

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Did you know?

Over 40% of the population has tried to lose weight at some point in the last 5 years – so you're certainly not alone