What are the key differences?
Use this side-by-side table for a quick overview of how Wegovy and Mounjaro compare.
|
|
|
| Feature |
Wegovy® Injection |
Mounjaro™ Injection |
| Active ingredient |
Semaglutide |
Tirzepatide |
| Mechanism of action |
GLP-1 receptor agonist |
Dual GIP and GLP-1 receptor agonist |
| Frequency |
Once weekly |
Once weekly |
| Administration |
Subcutaneous (under the skin) |
Subcutaneous (under the skin) |
| Dosing options |
0.25 mg, 0.5 mg, 1 mg, 1.7 mg, and 2.4 mg |
2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15 mg |
| Storage |
Refrigerated (long-term) |
Refrigerated (long-term) |
| Clinical weight loss |
Approximately 15% (average) |
Approximately 15% to 22.5% (average) |
Frequently asked questions
How does Wegovy work compared with Mounjaro?
Wegovy: Wegovy (semaglutide) targets the GLP-1 receptor to help regulate appetite and increase fullness.
Mounjaro: Mounjaro (tirzepatide) targets both GIP and GLP-1 receptors, offering a dual-pathway mechanism for weight management.
How do the doses increase over time for Wegovy and Mounjaro?
Wegovy: Doses typically escalate through 0.25 mg, 0.5 mg, 1 mg, 1.7 mg, and 2.4 mg weekly pens.
Mounjaro: Treatment usually starts at 2.5 mg and can be increased through 5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15 mg weekly doses, depending on suitability.
Do you use Wegovy and Mounjaro in the same way?
Wegovy: Wegovy is injected subcutaneously once weekly and is generally a straightforward injection routine.
Mounjaro: Mounjaro is also a once-weekly subcutaneous injection, but practical handling steps can differ and may involve priming and careful preparation before dosing.
What do I need to know about pregnancy and contraception when taking Wegovy or Mounjaro?
Wegovy: Effective contraception is recommended. If pregnancy occurs, stop treatment and seek clinical advice. Wegovy is usually stopped about 2 months before trying to conceive.
Mounjaro: Effective contraception is also recommended. Women taking oral contraceptives may need additional barrier protection during treatment initiation and after dose increases. Mounjaro is usually stopped around 8 weeks before conception.
Understanding these key differences can help individuals, in consultation with their healthcare providers, make informed decisions that align with their health goals and lifestyle preferences. For a deeper dive into popular weight loss medications, click here.
