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Adeel Arshad

Authored on 24 January 2024 by Adeel Arshad,

Reviewed 24 January 2024 by Dr Ruch Karunadasa.

Rizatriptan Orodispersable


Rizatriptan orodispersible tablets belong to a class of medicines called selective serotonin 5-HT1B/1D receptor agonists. It's a painkiller specifically used to relieve migraine attacks.

Medication effect duration

Like any other prescription medication you must consult a doctor before using it. PrivateDoc offers a confidential free consultation service that may result in you receiving a prescription for Rizatriptan Orodispersable, if it can prescribed safely.


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What is Rizatriptan Orodispersible?

Rizatriptan Orodispersible tablets treat the headache phase of your migraine attack. Treatment with Rizatriptan Orodispersible tablets reduces swelling of blood vessels surrounding the brain. This swelling results in the headache pain of a migraine attack.

How much does Rizatriptan Orodispersable cost?

Rizatriptan Orodispersable medication pack

Packs and prices

Prescription included
Prescription included

Who can use Rizatriptan Orodispersible

Do not take Rizatriptan Orodispersible tablets if you:

  • are allergic to rizatriptan benzoate or any of the other ingredients of this medicine
  • have moderately severe or severe high blood pressure, or mild high blood pressure that is not controlled by medication
  • have or have ever had heart problems including heart attack or pain on the chest (angina) or you have experienced heart disease related signs
  • have severe liver or severe kidney problems
  • have had a stroke (cerebrovascular accident CVA) or mini stroke (transient ischaemic attack TIA)
  • have blockage problems with your arteries (peripheral vascular disease)
  • are taking monoamine oxidase (MAO) inhibitors such as moclobemide, phenelzine, tranylcypromine, or pargyline (drugs against depression), or linezolid (an antibiotic), or if it has been less than two weeks since you stopped taking MAO inhibitors
  • are now taking ergotamine-type medications, such as ergotamine or dihydro-ergotamine to treat your migraine or methysergide to prevent a migraine attack
  • are taking any other drug in the same class, such as sumatriptan, naratriptan or zolmitriptan to treat your migraine.

For further information and contraindications please see the patient information leaflet

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How to take Rizatriptan Orodispersable

Rizatriptan tablets are used to treat migraine attacks. Take Rizatriptan tablets as soon as possible after your migraine headache has started. Do not use it to prevent an attack.Rizatriptan tablets (rizatriptan benzoate) dissolve in the mouth.

  • Open the Rizatriptan tablets blister pack with dry hands
  • The orodispersible tablet should be placed on your tongue, where it dissolves and can be swallowed with the saliva
  • The orodispersible tablets can be used in situations in which liquids are not available, or to avoid the nausea and vomiting that may accompany the ingestion of tablets with liquids.

If migraine returns within 24 hours:-

In some patients, migraine symptoms can return within a 24-hour period. If your migraine does return you can take an additional dose of Rizatriptan tablets. You should always wait at least 2 hours between doses.

If after 2 hours you still have a migraine:-

If you do not respond to the first dose of Rizatriptan tablets during an attack, you should not take a second dose of Rizatriptan tablets for treatment of the same attack. It is still likely, however, that you will respond to Rizatriptan tablets during the next attack.

Do not take more than 2 doses of Rizatriptan tablets in a 24-hour period, (for example, do not take more than two 10mg or 5mg orodispersible tablets in a 24- hour period). You should always wait at least 2 hours between doses.

For further information and dosage please see the patient information leaflet

Possible side effects

Like all medicines, Rizatriptan can cause side effects, although not everybody gets them. The following side effects may happen with this medicine, although some of the symptoms listed may have been caused by the migraine attack itself.

In adult studies, the most common side effects reported were dizziness, sleepiness and tiredness.

Common (affects 1 to 10 users in 100)

  • tingling (paraesthesia), headache, decreased sensitivity of skin (hypoaesthesia), decreased mental sharpness, insomnia.
  • fast or irregular heart beat (palpitation).
  • flushing (redness of the face lasting a short time).
  • throat discomfort.
  • feeling sick (nausea), dry mouth, vomiting, diarrhea, indigestion (dyspepsia).
  • feeling of heaviness in parts of the body, neck pain, stiffness.
  • pain in abdomen or chest.

Tell your doctor right away if you have symptoms of allergic reactions, serotonin syndrome, heart attack or stroke.

For further information and a full list of possible side effects please see the patient information leaflet

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