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Adeel Arshad

Authored on 24 January 2024 by Adeel Arshad,

Reviewed 24 January 2024 by Dr Ruch Karunadasa.

Trimovate Cream

Cream medication

Trimovate combines clobetasone, oxytetracycline and nystatin in a cream form to help combat dry skin conditions such as eczema/dermatitis which may also be infected.

Medication effect duration

Like any other prescription medication you must consult a doctor before using it. PrivateDoc offers a confidential free consultation service that may result in you receiving a prescription for Trimovate Cream if it is deemed appropriate and Trimovate Cream Application can prescribed safely.

Skin treatment

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Active ingredients

Trimovate is a combination cream which contains three active ingredients. These are –

Clobetasone Butyrate 0.05%

Oxytetracycline 3.0%

Nystatin 100,000 per gram

The cream is yellow in colour

How much does Trimovate cost?

What conditions can Trimovate be used for

Trimovate can be used to treat many conditions of the skin where a bacterial or fungal infection is also confirmed or suspected. These include but are not limited to –

  • Dermatitis (atopic, discoid, stasis, contact or seborrheic)
  • Eczema
  • Psoriasis
  • Nappy rash
  • Intertrigo (inflammation caused by skin to skin friction)

Trimovate contains a stronger steroid product compared to hydrocortisone, but not as strong as Betnovate (betamethasone) or Dermovate (clobetasol).

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How to use Trimovate

Trimovate is formulated to be applied topically to the affected skin only.

The cream should be applied sparingly to the affected area, taking care not to get too much on the surrounding healthy skin. Application of the cream is usually once or twice a day until the condition has improved. Once the symptoms have settled, treatment should be stopped or switched to a less potent preparation.

Continuous treatment with Trimovate should be for no longer than seven days. If you have not seen any improvement in your condition within this timeframe, or if your symptoms worsen, then this should be reviewed by your GP. Patients need to allow enough time for the cream to be absorbed before applying any other emollient. If the cream is being applied to an area other than the hands, then patients need to make sure they wash their hands thoroughly after each application.

Trimovate can be used in all age groups including children and the elderly. The cream should always be used in accordance with the prescribers instructions.

Who cannot use Trimovate

Renal/Hepatic Impairment – if applying the cream to a large surface area where systemic absorption may occur, then metabolism and excretion may be delayed which may lead to increased possibility of toxicity. Care should be taken when using in this patient group (short duration and minimum quantity).

You should not use Trimovate if you –

  • Have a known allergy to any of the active ingredients or any of the excipients of the cream
  • Have a primary viral infection of the skin
  • Have primary skin lesions which could be a result of a bacterial, fungal or yeast infection
  • Have a confirmed skin infection caused by Acinetobacter species, methicillin resistant Staphylococcus aureus (MRSA), Pseudomonas species, Proteus species Serratia species or Streptococcus B
  • Are trying to treat rosacea or acne with Trimovate.
  • Have itchy skin without any inflammation.

Depending on site of administration, systemic absorption is possible. Special care should be taken to avoid any contact with the eyes or the area surrounding the eyes. Other factors which may contribute towards systemic absorption include –

  • How long the drug treatment is likely to be
  • If you are applying the cream to a large surface area
  • Use on thin skin such as the face
  • Use on broken skin
  • Occlusion
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Pregnancy and breastfeeding

There is limited data available about the use of clobetasone during pregnancy in humans. In animal studies, systemic absorption has been shown to cause foetal developmental abnormalities. The use in pregnant females should be limited to cases where the potential benefits greatly outweigh the risks. Even in these cases, use should be limited to as small an amount as possible for the shortest duration of treatment.

Tetracyclines administered systemically can have a negative impact on the development of children’s teeth and bones. This being said, the levels absorbed via topical administration are likely to be too small to have any negative effects on the unborn child.

The effects of clobetasone with nystatin and oxytetracycline during breastfeeding have not been established. Therefore, it is not known whether there is enough systemic absorption during use for it to affect breast milk. Use should be limited to when benefits greatly outweigh the risks. If breastfeeding, the cream should not be applied to the breasts in case there is accidental ingestion by the infant. As stated above, it’s use should be restricted to small amounts and for as short a duration as possible.

Side effects

Side effects with Trimovate are very rare. Patients may experience some localised allergic reactions and hypersensitivity reactions such as contact dermatitis.

Systemic absorption may lead to Cushing’s Syndrome or hypothalamic-pituitary adrenal axis suppression. Contact with the eyes can lead to the development of glaucoma, cataracts or blurred vision.

In the event of an overdosage, treatment should be reduced gradually to avoid the risk of glucocorticosteroid insufficiency.

Some patients may also experience opportunistic skin infections.

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