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Adeel Arshad

Authored on 24 January 2024 by Adeel Arshad,

Reviewed 24 January 2024 by Dr Ruch Karunadasa.

Estradot Patches

HRT medication

Hormone replacement therapy (HRT) for oestrogen deficiency symptoms in postmenopausal women.

Medication effect duration

Like any other prescription medication you must consult a doctor before using it. PrivateDoc offers a confidential free consultation service that may result in you receiving a prescription for Estradot Patches if it is deemed appropriate and Estradot Patches can prescribed safely.

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What are Estradot Patches?

Estradot Patches are used for Hormone replacement therapy (HRT) for oestrogen deficiency symptoms in postmenopausal women.

Estradot 50, 75 and 100 only:
Prevention of osteoporosis in postmenopausal women at high risk of future fractures who are intolerant of, or contraindicated for, other medicinal products approved for the prevention of osteoporosis.

How much do Estradot Patches cost?

Estradot Patches medication


25 37.5 50 75 100

Pack size

How do you use Estradot patches?

Estradot is administered as continuous therapy (uninterrupted application twice weekly).

In women with an intact uterus, Estradot should be combined with a progestagen approved for addition to oestrogen treatment in a continuous sequential dosing scheme: the oestrogen is dosed continuously. The progestagen is added for at least 12 to 14 days of every 28-day cycle, in a sequential manner.

Unless there is a previous diagnosis of endometriosis, it is not recommended to add a progestagen in hysterectomised women.

In women who are not taking HRT or women transferring from a continuous combined HRT product, treatment may be started on any convenient day. In women transferring from a sequential HRT regimen, treatment should begin the day following completion of the prior regimen.

Method of administration:

The adhesive side of Estradot should be placed on a clean, dry area of the abdomen. Estradot should not be applied to the breasts.

Estradot should be replaced twice weekly. The site of application must be rotated, with an interval of at least 1 week allowed between applications to a particular site. The area selected should not be oily, damaged, or irritated. The waistline should be avoided, since tight clothing may dislodge the patch. The patch should be applied immediately after opening the sachet and removing the protective liner. The patch should be pressed firmly in place with the palm of the hand for about 10 seconds, making sure there is good contact, especially around the edges.

In the event that a patch should fall off, the same patch may be reapplied. If necessary, a new patch may be applied. In either case, the original treatment schedule should be continued. The patch may be worn during bathing.

If a woman has forgotten to apply a patch, she should apply a new patch as soon as possible. The subsequent patch should be applied according to the original treatment schedule. The interruption of treatment might increase the likelihood of irregular bleeding and spotting.

Read the Patient Information Leaflet

Pregnancy and lactation


  • Estradot is not indicated during pregnancy. If pregnancy occurs during medication with Estradot, treatment should be withdrawn immediately.
  • The results of most epidemiological studies to date relevant to inadvertent foetal exposure to oestrogens indicate no teratogenic or foetotoxic effects.


  • Estradot is not indicated during lactation.

Side effects

Very common (1 in 10 people or more):

  • Headaches, skin irritation, bruising, bleeding or swelling where the patch has been applied painful or tender breasts, period pain, or irregular periods..

Common (1 in 10 people or less):

  • Anxiety and depression, disturbed sleep, diarrhoea, abdominal pains, nausea, feeling bloated, dry or itchy skin, rashes, spots, enlarged breasts, heavy periods, irregular bleeding of the vagina, vaginal inflammation, vaginal discharge, severe uterine muscle contractions, unusual growth in the lining of the womb, fluid retention, changes in body weight, feeling weak, or pain in the back and limbs.

Uncommon (1 in 100 people or less):

  • Migraines, feeling faint, high blood pressure, vomiting, discoloured skin, or impaired tests for liver function.

Rare (1 in 1,000 people or less):

  • Tingling or numbness in hands and feet, blood clots, hair loss, gallstones, weak muscles, uterine muscle growths, cysts or polyps, or changes in libido.

Very rare (1 in 10,000 people or less):

  • Severe allergic reactions (shortness of breath, swelling, hives, dizziness) spasms of the head, eyes and neck, skin lesions, discomfort while using contact lenses, excess hair growth, or increased intolerance of carbohydrates.

This is only a summary, please refer to patient information leaflet provided or link below for comprehensive list. Patient Information Leaflet

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Estradot Patches should not be used by women with any of the following conditions:

  • Known, past or suspected breast cancer
  • Known or suspected oestrogen-dependent malignant tumours (e.g. endometrial cancer);
  • Undiagnosed genital bleeding;
  • Untreated endometrial hyperplasia;
  • Previous or current venous thromboembolism (deep venous thrombosis, pulmonary embolism);
  • Known thrombophilic disorders (e.g. protein C, protein S, or antithrombin deficiency, see section 4.4);
  • Active or recent arterial thromboembolic disease (e.g. angina, myocardial infarction);
  • Acute liver disease, or a history of liver disease as long as liver function tests have failed to return to normal;
  • Known hypersensitivity to the active substance or to any of the excipients listed in section 6.1;
  • Porphyria.
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