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Mounjaro Dose Schedule: Complete Month-by-Month Guide

As of 2026, Mounjaro (tirzepatide) is an established once-weekly injection in the UK for adults with obesity, or overweight with a weight-related comorbidity, used alongside a reduced-calorie diet and increased physical activity. It targets GLP-1 and GIP receptors to help reduce appetite and support weight loss, with dosing increased in clear steps under clinical supervision.

Mounjaro KwikPen devices

UK prescribers and patients now have substantial real-world experience with titration, injection technique, missed-dose rules, and follow-up, alongside the SURPASS trial programme that supported licensing. Dose escalation and monitoring are a routine part of obesity care rather than an experimental phase.

Mounjaro remains one of the most effective licensed options in its class when used as part of a broader plan. The table below summarises the standard month-by-month titration many new starters are guided through in practice, up to the 15 mg maximum weekly maintenance dose when appropriate.

The Mounjaro Dosage Schedule

Timeline Dose Phase Weekly Dose (mg) Duration
Month 1 Starting Dose 2.5 mg 4 Weeks
Month 2 Step-up Dose 5 mg 4 Weeks
Month 3 Step-up Dose 7.5 mg 4 Weeks
Month 4 Step-up Dose 10 mg 4 Weeks
Month 5 Step-up Dose 12.5 mg 4 Weeks
Month 6+ Maximum maintenance dose 15 mg Ongoing

Most people who are new to Mounjaro and not switching from another incretin-based injection will follow the titration above: each step usually lasts four weeks before increasing, unless your clinician advises a slower schedule or a lower maintenance dose.

Mounjaro medication packaging

The 15 mg strength is the highest licensed weekly maintenance dose. Not everyone needs or tolerates the maximum; some patients remain on a lower dose with good effect. For how Mounjaro compares with other medicines and how doses differ, see our Mounjaro vs Wegovy guide. For semaglutide (Wegovy), see our Wegovy dose schedule article.

Do all patients have to reach the maximum dose of Mounjaro?

The use of Mounjaro should be supervised by a qualified clinician who will monitor your response to treatment and any side effects.

In some circumstances patients may not be able to tolerate the higher doses of Mounjaro, but they can still experience benefit on a lower dose. In these situations patients may remain on a lower dose rather than stepping up to 12.5 mg or 15 mg.

Continuing below the licensed maximum can be appropriate under supervision when the balance of benefit, side effects, and individual goals supports it. Your clinician can explain what applies in your case.

The importance of a treatment plan whilst taking Mounjaro

It is important to actively engage with your treatment plan when using Mounjaro. The medicine is taken once weekly, with dose changes guided by your prescriber, typically in four-week intervals from 2.5 mg towards a maintenance dose up to 15 mg when suitable.

Attend follow-up consultations when invited, report persistent side effects early, and follow the missed-dose guidance in your patient information leaflet (generally if you miss a dose, you can take it within four days; otherwise skip and resume on your usual day).

A well managed plan is essential for long-term success. PrivateDoc recommends using a single coordinated provider for your Mounjaro treatment as part of overall weight management.

How do I switch to Mounjaro from another weight loss injection?

You must not use Mounjaro together with Wegovy, another GLP-1 weekly injection, or Saxenda (daily liraglutide). Only one weight loss injectable medicine should be used at any time.

When changing between medicines, prescribers use a washout gap and select a starting dose that reflects what you were on before. This is individual; do not attempt to self-switch.

For context on moving between injectable weight loss medicines, you may find it helpful to read staying on Mounjaro or switching to Wegovy and what happens when you switch from Mounjaro to Wegovy. Any switch to or from Mounjaro must be planned with your prescriber.

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